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【熱門】InvivoGen 疫苗佐劑 (Vaccine adjuvants)
【InvivoGen 疫苗佐劑 (Vaccine adjuvants)】
疫苗佐劑(Vaccine adjuvants)又稱免疫增強劑或免疫調節劑，通常使用於引發抗體反應的強度不盡理想，或製造疫苗的抗原劑量短缺時。
添加佐劑的好處包括:
(1)促進免疫系統對抗原的交互作用。
(2)誘發人體產生特定的免疫反應：例如刺激單一種類免疫球蛋白的製造，促進毒殺性（cytotoxic）或輔助性T淋巴球(helper T lymphocyte)的增生。
(3)促進免疫反應的品質(包括反應的強度與持續的時間) 。
(4)以較低的抗原劑量、較少的追加劑次引發相同強度的免疫反應。
(5) 降低某些抗原引發的副作用。
(6)可作為疫苗成份的溶劑。
疫苗佐劑不僅可以調節免疫反應的強度，還可以將疫苗的反應類型微調為所需的反應類型。疫苗抗原的免疫反應可分為Th1型和Th2型。Th1型主要產生細胞媒介的免疫反應，對抗細胞內病原體。Th2型是產生中和抗體反應的體液免疫。一般經典佐劑只誘導強效Th2型反應，對於針對病毒免疫的Th1型效果不顯著，所以目前的挑戰是開發有效活化Th1型免疫反應的新型佐劑。隨著天然免疫研究的深入研究，模式識別受體（pattern recognition receptors, PRRs）的天然配體(ligand)或合成活化劑(agonist)逐漸脫穎而出。初期研究發現當與鋁佐劑(alum)或油乳佐劑(emulsion adjuvants)結合使用時，它們能有效引導Th1型免疫反應。
InvivoGen提供優質疫苗佐劑，包括鋁佐劑(Alum)，油乳佐劑(emulsions)，弗式佐劑(CFA)和VacciGrade™等級PRR ligands，方便用於疫苗開發研究。
| Product |
Description |
Quantity |
Catalog |
| Alum and Emulsions |
| AddaVax™ |
Squalene-Oil-in-water - Th1/Th2 response |
10 |
vac-adx-10 |
| Adju-Phos® adjuvant |
Aluminium phosphate gel - Th2 Response |
250 ml |
vac-phos-250 |
| Alhydrogel® adjuvant 2% |
Aluminium hydroxide gel (Alum) - Th2 Response |
250 ml |
vac-alu-250 |
| AddaS03™ |
AS03 -like Vaccine Adjuvant |
10 mL |
vac-as03-10 |
| CFA |
Complete Freund’s Adjuvant - Th1 response |
10 ml 6 x 10 ml |
vac-cfa-10 vac-cfa-60 |
| IFA |
Incomplete Freund’s adjuvant - Th2 response |
10 ml 6 x 10 ml |
vac-ifa-10 vac-ifa-60 |
| Quil-A® adjuvant |
Purified triterpenoid saponin |
1 g |
vac-quil |
| PRR Ligands |
| 2’3’-c-di-AM(PS)2 (Rp,Rp) VacciGrade™ |
2’3’ bisphosphorothioate analog of c-di-AMP - STING agonist |
500 µg |
vac-nacda2r |
| 2’3’-cGAMP VacciGrade™ |
Cyclic [G(2’,5’)pA(3’,5’)p] - STING agonist |
1 mg |
vac-nacga23 |
| c-di-AMP VacciGrade™ |
Cyclic diadenylate monophosphate - STING agonist |
1 mg |
vac-nacda |
| c-di-GMP VacciGrade™ |
Cyclic diguanylate monophosphate - STING agonist |
1 mg |
vac-nacdg |
| CL401 VacciGrade™ |
Chimeric molecule - TLR2 & TLR7 agonist |
5 mg |
vac-c401-5 |
| CL413 VacciGrade™ |
Chimeric molecule - TLR2 & TLR7 agonist |
5 mg |
vac-c413-5 |
| CL429 VacciGrade™ |
Chimeric molecule - TLR2 & NOD2 agonist |
5 mg |
vac-c429 |
| Flagellin FliC VacciGrade™ |
Recombinant flagellin from S. typhimurium - TLR5 agonist |
50 µg |
vac-fla |
| Imiquimod VacciGrade™ |
Imidazoquinoline compound -TLR7 agonist |
5 mg |
vac-imq |
| LPS-EB VacciGrade™ |
Lipopolysaccharide from E. coli 0111:B4 strain - TLR4 agonist |
5 x 106 EU |
vac-3pelps |
| MPLA-SM VacciGrade™ |
Monophosphoryl lipid A from S. minnesota R595 - TLR4 agonist |
1 mg |
vac-mpla |
| MPLAs Vaccigrade™ |
Synthetic monophosphoryl lipid A - TLR4 agonist |
1 mg |
vac-mpls |
| ODN 1585 VacciGrade™ |
CpG ODN, Class A (murine) - TLR9 agonist |
1 mg |
vac-1585-1 |
| ODN 1826 VacciGrade™ |
CpG ODN, Class B (murine) - TLR9 agonist |
1 mg |
vac-1826-1 |
| ODN 2006 VacciGrade™ |
CpG ODN, Class B (human) - TLR9 agonist |
1 mg |
vac-2006-1 |
| ODN 2395 VacciGrade™ |
CpG ODN, Class C (human/murine) - TLR9 agonist |
1 mg |
vac-2395-1 |
| Pam3CSK4 VacciGrade™ |
Synthetic triacylated lipoprotein - TLR1/2 agonist |
1 mg |
vac-pms |
| Poly(I:C) (HMW) VacciGrade™ |
Polyinosine-polycytidylic acid -TLR3 agonist |
10 mg |
vac-pic |
| R848 VacciGrade™ |
Imidazoquinoline compound -TLR7/8 agonist |
5 mg |
vac-r848 |
| TDB VacciGrade™ |
Synthetic analog of the cord factor - Mincle agonist |
2 mg |
vac-tdb |